NEJM This Week

Featuring articles on kallikrein inhibition in hereditary angioedema, tight glycemic control in critically ill children, genetic drivers in the DiGeorge syndrome, MRI risks for patients with a pacemaker or ICD, and unburdening Mifeprex; a review article on screening for Chlamydia trachomatis infections in women; a case report of a woman with fatigue, weight loss, and skin lesions; and Perspective articles on recreational cannabis, on Medicare's Merit-Based Incentive Payment System, on applied research and development in health care, and on the death of animals in medical school.

Featuring articles on survival and neurodevelopment among periviable infants, osimertinib in EGFR-mutated lung cancer, bariatric surgery or medical therapy for type 2 diabetes, baricitinib in rheumatoid arthritis, and opioid prescribing and risk of long-term use; a review article on FDA regulation of prescription drugs; a case report of a man with hematuria and a retroperitoneal mass; and Perspective articles on addressing the fentanyl threat to public health, on adjusting risk adjustment, on new vaccines against epidemic infectious diseases, and on the Common Rule, updated.

Featuring articles on thromboprophylaxis after arthroscopy and leg casting, prospective surveillance of medical-device safety, outcomes with genetic lesions in myelodysplastic syndrome, and Middle East respiratory syndrome; a review article on fever in the returning traveler; a case report of a girl with growth retardation and respiratory failure; and Perspective articles on powerful ideas for global access to medicines, on social risk factors and equity in Medicare payment, and on whether value-based purchasing should take social risk into account.

Featuring articles on antiandrogen therapy in recurrent prostate cancer, crisis prevention in sickle cell disease, comparing ventricular assist systems for heart failure, intrapericardial left ventricular assist device, and a take on tumor immunity; review articles on long-acting reversible contraception and on drug-development challenges for small companies; a Clinical Problem-Solving article on making the connection; and Perspective articles on Medicare payment for behavioral health integration, on the economic effects of Medicaid expansion in Michigan, on caring for children by supporting parents, and on early exposure to end-of-life conversations in medical training.

Featuring articles on bezlotoxumab to prevent recurrent C. difficile infection, therapeutic hypothermia after in-hospital cardiac arrest, recombinant vesicular stomatitis virus Ebola vaccine, tobacco-product use in the United States, and an 11-year update on trial registration; a review article on renal-cell carcinoma; a case report of a man with cardiac sarcoidosis, diplopia, and weakness; and Perspective articles on repealing the ACA without a replacement, on allocating organs to cognitively impaired patients, and on intimate choices, public threats.

Featuring articles on ocrelizumab in primary progressive multiple sclerosis, ocrelizumab vs. interferon beta-1a in relapsing MS, a "zombie" outbreak caused by a synthetic cannabinoid, extensively drug-resistant tuberculosis, and immunity to Mycobacterium tuberculosis; a review article on obesity; a case report of a woman with acute liver failure; and Perspective articles on transparency and trust, on population health, on cost-effectiveness analysis 2.0, and on the psychocatalytic benefits of the unexpected.

Featuring articles on amitriptyline and topiramate for childhood migraine, 177Lu-Dotatate in midgut neuroendocrine tumors, tranexamic acid in coronary-artery surgery, rethinking the ban on blood donations, and mitochondrial donation; a review article on colorectal cancer screening; a case report of a woman with gradually progressive loss of language; and Perspective articles on eliminating cholera transmission in Haiti, care for the vulnerable vs. cash for the powerful, harnessing patients' voices to improve care, Section 1332 waivers and state-led reform, and the 21st Century Cures Act.

Featuring articles on acute kidney injury in critically ill children, disease phenotypes and multilocus genomic variation, ticagrelor vs. clopidogrel in peripheral artery disease, RNAi inhibitor of PCSK9, and delivering on oligonucleotide therapeutics; review articles on the large pharmaceutical company perspective and on arrhythmogenic right ventricular cardiomyopathy; a Clinical Problem-Solving article describing after the party's over; and Perspective articles on the end of Obamacare, on oligonucleotide therapeutics, and on a view from the edge.

Featuring articles on the cardiovascular safety of celecoxib, naproxen, or ibuprofen; fatty acids in pregnancy and wheeze and asthma in offspring; single versus bilateral internal-thoracic-artery grafts; selumetinib for plexiform neurofibroma; and chimeric antigen receptor T cells in glioblastoma; a review article on myasthenia gravis; a case report of a girl with recurrent vomiting; and Perspective articles on maintaining insurance access under Trump, on engineering social incentives for health, on supporting family caregivers of older Americans, and on improving maintenance of certification.

This summary covers the issue of June 13, 2013. Featured are articles on targeted versus universal decolonization for ICU infection, SALL4 in aggressive hepatocellular carcinoma, clinical findings in H7N9 virus infection, racemic adrenaline and inhalation in bronchiolitis, point-of-care diagnostics and innovation in global health, and treating iron overload; a review article on acute high-altitude illnesses; a case report of a woman with recurrent episodes of altered consciousness; and Perspective articles on envy -- a strategy for reform, on reevaluating "made in America," on the role of the NIH in nurturing clinician-scientists, and on assessing competency for concealed-weapons permits.