NEJM This Week

Featuring articles on a monoclonal antibody in mild Alzheimer's disease, brentuximab vedotin in advanced Hodgkin's lymphoma, myocardial infarction after influenza infection, and glecaprevir and pibrentasvir for genotype 1 or 3 HCV; a review article on hemorrhagic shock; a case report of an infant with hypoglycemia; and Perspective articles on clinician burnout, on the President's Emergency Plan for AIDS Relief, and on treating and preventing HIV with generic drugs.

Featuring articles on gene transfer in hemophilia A, CAR T cells for B-cell lymphoma, and MRI scanning in patients with cardiac devices; a review article on chronic graft-versus-host disease; a case report of a woman with headache, anemia, and thrombocytopenia; and Perspective articles on better-quality compounded drugs, on emergency legal authority and the opioid crisis, and on health care professionals and law enforcement.

Featuring articles on PCI in acute myocardial infarction with cardiogenic shock, CMV prophylaxis with letermovir, delayed versus immediate cord clamping in preterm infants, outcomes of shunting vs. endoscopic treatment for infant hydrocephalus in Uganda, a common signature of DNA damage, and putting the patient back together; a review article on hearing loss in adults; a case report of a woman with recurrent chest pain; and Perspective articles on understanding the Planned Parenthood divide, on the quiet room, on evidence-based health policy, and on whether there is merit in merit aid.

Featuring articles on a WHO Safe Childbirth Checklist Program in India, noninvasive ablation of ventricular tachycardia, the effects of sotagliflozin added to insulin, a vaccine for serotype B meningococcus, and the less-is-more crusade; a review article on HIV-associated kidney diseases in the antiretroviral era; a case report of a woman with seizures and progressive dystonia; and Perspective articles on drug companies' liability for the opioid epidemic, on coupling policymaking with evaluation, and on using Medicare prices.

Featuring articles on gene therapy for hemophilia B, hormonal contraception and breast-cancer risk, pharmacomechanical catheter-directed thrombolysis, PDUFA VI, and the risk of recurrence in breast cancer; a review article on necrotizing fasciitis; a Clinical Problem-Solving article on an unusual cause of leg pain; and Perspective articles on Medicaid coverage for family planning, on which road to universal coverage, on how to think about "Medicare for All", and on Christiaan Barnard's heart transplantations.

Featuring articles on romosozumab or alendronate for fracture prevention, Ebola RNA persistence in semen of survivors, Ebola vaccines, glecaprevir and pibrentasvir for HCV, the sustainability of the blood supply, and reovirus infection in celiac disease; a review article on delirium; a case report of a girl with failure to thrive; and Perspective articles on the first FDA approval agnostic of cancer site, on misdirections in informed consent, and on voluntary site accreditation.

Featuring articles on rivaroxaban in stable cardiovascular disease, obinutuzumab vs. rituximab in follicular lymphoma, combined nivolumab and ipilimumab in melanoma, and per-protocol analyses of pragmatic trials; review articles on noninferiority trials and on electrolyte disturbances in alcohol-use disorder; a Clinical Problem-Solving article describing an element of unsteadiness; and Perspective articles on the potential of patient-reported outcomes; on tragedy, perseverance, and chance; and on the other end of the stethoscope.

Featuring articles on anacetrapib in atherosclerotic vascular disease, exenatide and cardiovascular outcomes in diabetes, oxygen in suspected acute myocardial infarction, rituximab after transplantation in mantle-cell lymphoma, investing in global health for our future, and the Lasker Award for mTOR discovery; a review article on red-cell transfusion; a case report of a woman with altered mental status and acute liver failure; and Perspective articles on the limits of the human mind, on the paradox of coding, and on ancillary care and study end points.

Featuring articles on canakinumab for atherosclerotic disease, bivalirudin vs. heparin in myocardial infarction, weight and other outcomes 12 years after gastric bypass, and genetic associations with gestation and preterm birth; review articles on food allergy and on thrombophilia testing; a case report of a woman with pain and swelling in the right hand and ankles; and Perspective articles on tuberculosis elimination in the United States, on a nicotine-focused framework for public health, and on the fate of FDA postapproval studies.

Featuring articles on the closure of patent foramen ovale in cryptogenic stroke, a rapid tuberculosis assay, hospital-readmission risk, and interfering frequencies getting deep; a review article on progress in radiotherapy; a case report of a young girl with pneumonia and her mother with hip pain; and Perspective articles on repeal, replace, repair, retreat and on partial Medicaid expansions under the ACA.

Featuring articles on angiotensin II for the treatment of vasodilatory shock, idarucizumab for dabigatran reversal, IgG endopeptidase in patients undergoing transplantation, midostaurin plus chemotherapy for AML, and screening of stem cells for clinical use; a review article on evidence for health decisions beyond RCTs; a Clinical Problem-Solving article that describes all that wheezes...; and Perspective articles on the cyberattack on Britain's National Health Service, on gabapentin and pregabalin for pain, and on recognizing sepsis as a global health priority.

Featuring articles on tocilizumab and prednisone taper in giant-cell arteritis, ventilation in preterm infants and respiratory function, abiraterone in metastatic prostate cancer, and the role of science in addressing the opioid crisis; a review article on mobile DNA in health and disease; a case report of a girl with vomiting, acidosis, and azotemia; and Perspective articles on alternative science and human reproduction, on the price of crossing the border for medications, and on turmoil in the individual insurance market.

Featuring articles on angiopoietin-like 3 and cardiovascular disease, enhanced prophylaxis for advanced HIV, implementation of medical homes, physician payment reform, and follicle-stimulating hormone and adiposity; a review article on subarachnoid hemorrhage; a case report of a woman with fever, headache, and myalgias; and Perspective articles on controlling the cost of Medicaid, on active surveillance for low-risk cancers, and on managing uncertainty.

Featuring articles on clonal hematopoiesis and coronary heart disease, pertuzumab plus trastuzumab in HER2-positive breast cancer, long-term results of the PIVOT prostate-cancer trial, diet and total and cause-specific mortality, Crimean–Congo hemorrhagic fever in Spain, and the march of science; a review article on amyotrophic lateral sclerosis; a case report of a pregnant woman with endocervical carcinoma; and Perspective articles on targeting unconscionable prescription-drug prices, on the economics of indication-based drug pricing, and on the chair grant.

Featuring articles on the effect of overweight and obesity in 195 countries, endometriosis-associated pain management with elagolix, the declining risk of sudden death in heart failure, CD55 and protein-losing enteropathy, and the macrophage and the heart; a review article on master protocols; a Clinical Problem-Solving article describing beating, fast and slow; and Perspective articles on undermining genetic privacy, on home-to-home time, on patient-reported outcomes, and on preserving the Fogarty International Center.