NEJM This Week

Featuring articles on MRI in prostate-cancer diagnosis, Zika virus and the blood supply, pembrolizumab adjuvant therapy for melanoma, and transfer RNA derivatives and tumor-cell growth; review articles on essential tremor and on idiopathic pulmonary fibrosis; a case report of a woman with a rash, hyponatremia, and uveitis; and Perspective articles on charting a path for improving performance measurement; on deployment of preventive interventions, and on moving on.

Featuring articles on triple inhalers in COPD, fish oil and dry eye disease, a BACE-1 inhibitor for Alzheimer's disease, the potential health effects of reducing nicotine, the IARC view on colorectal screening, and the best medical care in the world; a review article on calciphylaxis; a Clinical Problem-Solving article describing the wrong frame of mind; and Perspective articles on care for undocumented immigrants, on reform at risk, on improving adoption of EHRs in psychiatric care, and on questionable admissions.

Featuring articles on tenecteplase vs. alteplase for thrombolysis in stroke, azithromycin for childhood mortality in Africa, safely preventing mother-to-child transmission of HIV, tweaking prenatal development, and on fueling metastatic prostate cancer; a review article on recognition of chemical-weapons attacks; a case report of a man with cardiomyopathy and ventricular tachycardia; and Perspective articles on strategies for reducing opioid-overdose deaths, on a silent contributor to opioid-overdose deaths, and on the long ride home.

Featuring articles on gene therapy for B-thalassemia, medical education and duty-hour flexibility, clinic and ambulatory blood pressure and mortality, and intussusception and rotavirus vaccination; a review article on placenta accreta spectrum; a case report of a woman with cardiac arrest; and Perspective articles on monoclonal antibodies for infectious diseases and on facing the U.S. saline shortage.

Featuring articles on Zika virus shedding in semen, two-year outcomes with a centrifugal-flow LVAD, genetic heterogeneity in large B-cell lymphoma, apalutamide in prostate cancer, the FDA breakthrough-drug designation, and an experimental approach to treating ALS; a review article on base excess in acid–base disorders; a case report of a woman with venous thromboembolism and pulmonary artery aneurysm; and Perspective articles on divisions, new and old; on the accessibility of medical diagnostic equipment; and on aligning efforts in global health.

Featuring articles on checkpoint inhibition in renal-cell cancer, blood-pressure reduction in black barbershops, child-to-adult change in overweight and type 2 diabetes, outpatient talc administration for pleurodesis, and the promise and reality of price transparency; a review article on epigenetics in disease prevention and mitigation; a Clinical Problem-Solving article describing a stream of consciousness; and Perspective articles on whether MACRA will improve physician reimbursement, on bedside computer vision, and on cousin Pam.

Featuring articles on adjuvant-therapy duration in colon cancer, detection of mutations to predict relapse of AML, cardiovascular safety of febuxostat, ibrutinib plus venetoclax in mantle-cell lymphoma, whether we are prepared for nuclear terrorism, and preserving Beethoven's hearing; a review article on tinnitus; a case report of a man with painless unilateral testicular swelling; and Perspective articles on hepatitis C in injection-drug users, on polluting developing brains, and on rethinking the criminalization of HIV exposure.

Featuring articles on H. pylori therapy for gastric cancer prevention, genetic protection against chronic liver disease, venetoclax-rituximab treatment in chronic lymphocytic leukemia, and high- vs. low-flow oxygen therapy in bronchiolitis; a review article on autoimmune polyendocrine syndromes; a case report of a man with HIV infection and a facial mass; and Perspective articles on Alzheimer's disease in physicians, on myth and measurement, on broken hearts and opened eyes, and on life as a depressed medical student.

Featuring articles on pregnancy outcomes after Zika virus infection, corneal endothelial cells and a kinase inhibitor for bullous keratopathy, treatment for cryptococcal meningitis, a genetic cause of juvenile myoclonic epilepsy, and eyeing up retinal plasticity; a review article on AIDS-associated cancers; a case report of a woman with shock and labile blood pressure; and Perspective articles on financial incentives and vulnerable populations, on addressing the quality-measurement conundrum, and on implementing machine learning in health care.

Featuring articles on quintupling inhaled glucocorticoids for childhood asthma, quadrupling inhaled glucocorticoids for adult asthma, prevention of mother-to-child HBV transmission, dueling EPO transcripts in erythrocytosis, and the FDA's track for cell-based therapies; a review article on primary Sjogren's syndrome; a case report of a man with new-onset seizures; and Perspective articles on wildfires and smoke, on physician-assisted death for psychiatric patients, and on tumors and transformations.

Featuring articles on steroids for septic shock, balanced crystalloids in noncritically ill adults, balanced crystalloids vs. saline in critically ill adults, and the expanding hydrogel; a review article on antibody-mediated encephalitis; a Clinical Problem-Solving article describing an unexpected expectoration; and Perspective articles on vaccination without litigation, on whether work can be required in the Medicaid program, on friction in the path to the use of biosimilar drugs, and on being out of the straitjacket.

Featuring articles on aspirin for VTE prophylaxis after orthopedic surgery, endovascular thrombectomy for stroke at 6 to 16 hours, neonatal vaccination with a rotavirus vaccine, larotrectinib in cancers with TRK fusions, and ethical payment to research participants; a review article on pleural disease; a case report of a woman with headache, subjective fever, and anemia; and Perspective articles on the psychology of clinical decision making, on controlling the swing of the opioid pendulum, on our other prescription drug problem, and on federal right-to-try legislation.

Featuring articles on sodium bicarbonate and acetylcysteine for angiography, edoxaban for cancer-associated venous thromboembolism, nusinersen for later-onset spinal muscular atrophy, and innervation in prostate cancer; review articles on the initial treatment of hypertension and on metastatic prostate cancer; a case report of a man with confusion after stem-cell transplantation; and Perspective articles on whether CVS-Aetna spell the end of business as usual, on medical devices in the real world, on when the CHIPs are down, and on caring for Ms. L.

Featuring articles on prazosin for trauma-related nightmares in veterans, daratumumab plus chemotherapy in myeloma, an anti-CCR4 antibody in HTLV-1-associated spastic paraparesis, and consequences of the 340B Drug Pricing Program; a review article on post-transplantation lymphoproliferative disorders; a case report of a newborn with thrombocytopenia, cataracts, and hepatosplenomegaly; and Perspective articles on redefining hypertension, on the judicial threat to public health innovation, on discounted drugs for needy patients and hospitals, and on rejuvenating regenerative medicine regulation.

Featuring articles on ablation for atrial fibrillation with heart failure, childhood kidney disease and risk of adult end-stage renal disease, CAR T cells in acute lymphoblastic leukemia, the challenging quest to improve rural health, and tackling the tumor and sparing the host; a Clinical Problem-Solving article on home sweet home; and Perspective articles on Donald Trump's mental health, on the public and the opioid-abuse epidemic, on the Regulatory Accountability Act of 2017, and on the myth of the milkmaid.