Summary: Featuring articles on Zika virus shedding in semen, two-year outcomes with a centrifugal-flow LVAD, genetic heterogeneity in large B-cell lymphoma, apalutamide in prostate cancer, the FDA breakthrough-drug designation, and an experimental approach to treating ALS; a review article on base excess in acid–base disorders; a case report of a woman with venous thromboembolism and pulmonary artery aneurysm; and Perspective articles on divisions, new and old; on the accessibility of medical diagnostic equipment; and on aligning efforts in global health.
