NEJM This Week

Featuring articles on upadacitinib or abatacept in rheumatoid arthritis, a nimble GWAS on Covid-19, life expectancy after bariatric surgery, an mRNA–based Covid-19 vaccine in nonhuman primates, and selection against pathogenic mitochondrial DNA; a review article on autophagy in human diseases; a case report of a man with confusion, fatigue, and garbled speech; and Perspective articles on health policy in a Biden administration or after a Trump election victory, on Covid-19 and the mandate to redefine preventive care, and on when all you have is quality of life. Supplement to the New England Journal of Medicine, Vol. 383, No. 16.

Featuring articles on empagliflozin in heart failure, cardiovascular outcomes with ertugliflozin in diabetes, dapagliflozin in chronic kidney disease, single or dual antiplatelet treatment after TAVI, on dying in a leadership vacuum, Covid-19 and implications for the health care system, and mending mitochondrial mutation; a review article on secondary mitral regurgitation; a case report of a man with lymphoma and abdominal pain; and Perspective articles on the role of market forces in U.S. health care, on embracing antiracism in medicine, and on improving clinical trial enrollment. Supplement to the New England Journal of Medicine, Vol. 383, No. 15.

Featuring articles on early rhythm-control therapy for atrial fibrillation, evolocumab in heterozygous pediatric familial hypercholesterolemia, atezolizumab in non–small-cell lung cancer, HPV vaccination and the risk of cervical cancer, and physician work hours and the gender pay gap; a review article on myelodysplastic syndromes; a Clinical Problem-Solving describing parroting lymphoma; and Perspective articles on health in aging, on ensuring uptake of vaccines against SARS-CoV-2, on an innovative approach to reducing gun suicides, and on the ritual of the table. Supplement to the New England Journal of Medicine, Vol. 383, No. 14.

Featuring articles on a RAS oncogene inhibitor at last, avelumab maintenance therapy in bladder cancer, lower-dose zinc for childhood diarrhea, antisense oligonucleotides for hereditary angioedema, and sussing out the sestrins; a review article on congenital adrenal hyperplasia due to 21-hydroxylase deficiency; a case report of a man with sudden cardiac arrest; and Perspective articles on competing visions for the future of health policy, on assessing the safety of glucose-lowering drugs, on Ebola response priorities in the time of Covid-19, and on a farewell gift from a mother. Supplement to the New England Journal of Medicine, Vol. 383, No. 13.

Featuring articles on exome sequencing analysis in stillbirth, a two-year trial of belimumab in lupus nephritis, nocturnal oxygen in COPD, adjuvant targeted therapy in melanoma, and daratumumab in refractory lupus; a review article on immune tolerance; a case report of a man with fever and shortness of breath after liver transplantation; and Perspective articles on consent to trainee involvement in pediatric care, on examining examinations conducted under anesthesia, on June Medical Services v. Russo, and on sticks and stones. Supplement to the New England Journal of Medicine, Vol. 383, No. 12.

Featuring articles on hydroxychloroquine for Covid-19 prophylaxis, subcutaneous or transvenous ICD therapy, Zika virus disease in Colombia, ofatumumab vs. teriflunomide in multiple sclerosis, and spending after state specialty-drug out-of-pocket caps; a review article on native-valve infective endocarditis; a Clinical Problem-Solving on being led astray; and Perspective articles on the National Academy of Medicine and the quality of health care, on care churn, on mental health and the Covid-19 pandemic, and on preventing a parallel pandemic. Supplement to the New England Journal of Medicine, Vol. 383, No. 6.

Featuring articles on nirsevimab for the prevention of RSV disease, RSV vaccination during pregnancy to protect infants, uterine-artery embolization or myomectomy for uterine fibroids, a trial of a therapeutic anti–yellow fever virus antibody, and a bad acid trip for sarcomas; a review article on chronic lymphocytic leukemia; a case report of a woman with chest pain, dyspnea, and shock; and Perspective articles on health care as an ongoing policy project, on Covid’s color line, and on the illusion of inclusion. Supplement to the New England Journal of Medicine, Vol. 383, No. 5.

Featuring articles on postexposure influenza prophylaxis, growth stunting and intestinal microbiota, multisystem inflammatory syndrome in children, and vitamin D supplements for the prevention of tuberculosis; a review article on coffee, caffeine, and health; a case report of a woman who died from Covid-19; and Perspective articles on border babies, on failing the test, on Covid-19 epidemiologic models, and on the pandemic as teacher. Supplement to the New England Journal of Medicine, Vol. 383, No. 4.

Featuring articles on ticagrelor and aspirin after a stroke or transient ischemic attack, an RNA early warning for rheumatoid arthritis flares, roflumilast cream for chronic psoriasis, timing of renal-replacement therapy in acute kidney injury, bilateral tumors, diagnosing and treating systemic racism, and structural solutions for the rarest of the rare; a review article on acute ischemic stroke; a case report of a woman with early breast cancer during the Covid-19 pandemic; and Perspective articles on stolen breaths, on creating real change at academic medical centers, on racial health disparities and Covid-19, and on uncertain trust. Supplement to the New England Journal of Medicine, Vol. 383, No. 3.

Featuring articles on an antisense oligonucleotide for SOD1 ALS, the treatment of familial ALS with a viral vector, angiogenesis and Covid-19, a multifactorial strategy to prevent serious fall injuries, and nemolizumab for atopic dermatitis; a review article on cervical spondylosis; a case report of a homeless man with Covid-19; and Perspective articles on social prescribing; on ensuring choice for people with kidney failure; on disease control, civil liberties, and mass testing; and on coronavirus and the Navajo Nation. Supplement to the New England Journal of Medicine, Vol. 383, No. 2.

Featuring articles on antibiotics for pneumonia in children, triple therapy for COPD, Apgar score and neonatal mortality in preterm infants, and rhythmic protein expression and the beta cell; a review article on bipolar disorder; a Clinical Problem-Solving on cryptic cachexia; and Perspective articles on four decades of HIV/AIDS; on age, complexity, and crisis; on the cost, price, and debt of medical education; and on blame. Supplement to the New England Journal of Medicine, Vol. 383, No. 1.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.