NEJM This Week

Featuring articles on cryoablation for atrial fibrillation, inhaled treprostinil in interstitial lung disease, a levonorgestrel vs. copper IUD for emergency contraception, the return of cardiac activity after withdrawal of life support, and antigen presentation by B cells in multiple sclerosis; a review article on atrial fibrillation; a case report of a man with transient vision loss; and Perspective articles on reimagining infective endocarditis care amid the opioid epidemic, on a medical “ecology of attention”, and on the surgeon and the mother. Supplement to the New England Journal of Medicine, Vol. 384, No. 4.

Featuring articles on inhibiting BCL11A to treat sickle cell disease and β-thalassemia, a polypill with or without aspirin in primary prevention, and neutralizing-antibody therapy in Covid-19; a review article on the effects of infection on natural immunity; a case report of a pregnant woman with ventricular tachycardia and shock; and Perspective articles on testing in a pandemic, on the Supreme Court and pandemic controls, and on incarceration and social death. Supplement to the New England Journal of Medicine, Vol. 384, No. 3.

Featuring articles on omecamtiv mecarbil in systolic heart failure, sotagliflozin in diabetes with heart failure, sotagliflozin for heart failure in diabetes and kidney disease, bupropion and naltrexone for methamphetamine use, and procuring oligodendrocytes after spinal cord injury; a review article on Ewing’s sarcoma; a case report of a woman with lethargy and altered mental status; and Perspective articles on the Purdue Pharma opioid settlement, on drug-coated devices for peripheral arterial disease, and on the doctor as street-level bureaucrat. Supplement to the New England Journal of Medicine, Vol. 384, No. 2.

Featuring articles on sitagliptin for prevention of acute GVHD, tocilizumab in Covid-19 pneumonia, rilonacept in recurrent pericarditis, vaginal mother-to-child transmission of cancer, and on whether the melanoma epidemic is real; a review article on osteoarthritis of the knee; a Clinical Problem-Solving on breathing for two; and Perspective articles on human molecular genetics and genomics, on Covid-19 and the undocumented Latinx community, and on the stress of Bayesian medicine. Supplement to the New England Journal of Medicine, Vol. 384, No. 1.

Featuring articles on the safety and efficacy of an RNA-based SARS-CoV-2 vaccine, dexamethasone in chronic subdural hematoma, sleuthing out a severe adult inflammatory disorder, hemoglobin transfusion thresholds in infants, and vaccinating against SARS-CoV-2; a review article on the pathophysiology of inflammatory bowel diseases; a case report of a man with memory loss and odd behavior; and Perspective articles on reimagining how policymakers identify safety-net hospitals, on Medicaid and child health equity, on the FDA approval of remdesivir, and on whiteouts. Supplement to the New England Journal of Medicine, Vol. 383, No. 27.

Featuring articles on ultrasound subthalamotomy for Parkinson’s disease, antenatal dexamethasone for early preterm birth, oral azacitidine maintenance therapy for AML, paclitaxel-coated devices in peripheral artery disease, and seizure frequency during pregnancy; a review article on estrogen receptor–positive breast cancer; a case report of a man with headache and Covid-19; and Perspective articles on the gift; on new order, new hope; on resilience in the face of Covid-19; and on holding up. Supplement to the New England Journal of Medicine, Vol. 383, No. 26.

Featuring articles on SARS-CoV-2 transmission among Marine recruits, SARS-CoV-2 transmission on an aircraft carrier, an mRNA vaccine against Covid-19 in older adults, a phase 1 trial of an RNA-based Covid-19 vaccine, and the cardiomyocyte and the mighty mitochondrion; a review article on severe Covid-19; a case report of a boy with seizure and hypocalcemia; and Perspective articles on health coverage and care for transgender people, on rethinking sex designations on birth certificates, on being interviewed while Black, and on the caregiver. Supplement to the New England Journal of Medicine, Vol. 383, No. 25.

Featuring articles on lipid lowering through activation of lipoprotein lipase, on a SARS-CoV-2 recombinant nanoparticle vaccine, on tocilizumab in Covid-19, and on survival with olaparib in prostate cancer; a review article on spontaneous coronary-artery dissection; a case report of a man with cancer and acute hypoxemia; and Perspective articles on the discovery of hepatitis C, on how Medicare Part D has failed to deliver savings to older adults, on a pandemic within a pandemic, and on Telephone. Supplement to the New England Journal of Medicine, Vol. 383, No. 24.

Featuring articles on pembrolizumab in microsatellite-unstable colorectal cancer, the effect of finerenone on chronic kidney disease outcomes, person-to-person spread of Andes virus, malaria chemoprophylaxis in sub-saharan Africa, and epigenetic regulation in prostate cancer; a review article on cytokine storm; a Clinical Problem-Solving on looking for the outsider; and Perspective articles on solving population-wide obesity, on the bottom of the health care rationing iceberg, on understanding questions and answers about Covid-19 vaccination, and on why we need black physicians in academic medicine. Supplement to the New England Journal of Medicine, Vol. 383, No. 23.

Featuring articles on once-weekly insulin icodec for type 2 diabetes; rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve; neutrophil elastase inhibition in bronchiectasis; laryngeal mask airway in neonatal resuscitation; women physicians and academic promotion; and wildfires, global climate change, and human health; a case report of a man with lymphadenopathy and petechiae; and Perspective articles on delaying pregnancy during a public health crisis, on banning genetic discrimination in life insurance, on reparations as a public health priority, and on entering a guilt-free zone. Supplement to the New England Journal of Medicine, Vol. 383, No. 22.

Featuring articles on golimumab and beta-cell function in type 1 diabetes, lorlatinib in ALK-positive lung cancer, hydroxychloroquine in patients with Covid-19, hydroxychloroquine with or without azithromycin in Covid-19, crafty killing of pathogenic microbes in the placenta, and physician–public defender collaboration; a review article on endometrial cancer; a case report of a woman with dark urine and weakness; and Perspective articles on the regulation of over-the-counter hearing aids, on transgender women on college athletic teams, and on unclaimed bodies in the anatomy lab. Supplement to the New England Journal of Medicine, Vol. 383, No. 21.

Featuring articles on antibiotics vs. appendectomy for appendicitis, immunogenicity of a candidate SARS-CoV-2 vaccine, intussusception after rotavirus vaccination in India, antibiotic resistance after mass azithromycin distribution, and automated alerts for patients at risk of clinical deterioration; a review article on esophageal motility disorders and gastroesophageal reflux disease; a case report of a woman with type 1 diabetes mellitus and obtundation; and Perspective articles on Covid-19 vaccine trials and incarcerated people, on delivering options for preventing and treating Covid-19, on racism and sickle cell disease, and on the care and treatment of black youth in America. Supplement to the New England Journal of Medicine, Vol. 383, No. 20.

Featuring articles on remdesivir for the treatment of Covid-19, colchicine in patients with chronic coronary disease, preventing falls and fractures in older people, understanding the origins of bilateral neuroblastoma, and a new experimental approach to retinal degeneration; a review article on migraine; a Clinical Problem-Solving on the absence of proof; and Perspective articles on shaping the future of veterans’ health care, on addressing physicians’ complicity in criminalizing communities, on contact tracing and the limits of persuasion, and on grieving for the out-of-practice. Supplement to the New England Journal of Medicine, Vol. 383, No. 19.

Featuring articles on osimertinib adjuvant therapy in EGFR-mutated non–small-cell lung cancer, a durable humoral response to SARS-CoV-2, low-dose edoxaban in atrial fibrillation, and exome sequencing for nonimmune hydrops fetalis; a review article on mild or moderate Covid-19; a case report of a man with chronic kidney disease; and Perspective articles on Operation Warp Speed’s strategy and approach, on evaluating and deploying Covid-19 vaccines, on pharmaceutical industry caution vs. federal acceleration of Covid-19 vaccine approval, and on the new stability. Supplement to the New England Journal of Medicine, Vol. 383, No. 18.

Featuring articles on dasatinib–blinatumomab in Ph-positive ALL, an anti–Siglec-8 antibody in gastritis and duodenitis, inhaled molgramostim therapy in autoimmune pulmonary alveolar proteinosis, treating Middle East Respiratory Syndrome, fibroblasts in rheumatoid arthritis, and how can we bridge the partisan divide and conquer Covid; a review article on sensory ganglionopathy; a case report of a man with abdominal pain, joint swelling, and skin lesions; and Perspective articles on whether the elections can end the health reform stalemate, on insurance coverage after job loss, on redoubling efforts to help Americans quit smoking, and on taking back our voices. Supplement to the New England Journal of Medicine, Vol. 383, No. 17.