Break Nutrition Show
Summary: Raphael Sirtoli is the co-founder of www.breaknutrition.com and hosts the Break Nutrition podcast to take a deep dive into the science behind nutrition and medical studies. He’s joined by recurring co-host Gabor Erdosi - the ‘adipocyte Jedi’ of the Lower Insulin Facebook group - to review papers exploring what causes diabetes, obesity and other metabolic disorders. Raphael also interviews a broad range of people, like researchers, engineers, doctors, nurses, philosophers and people with inspiring personal health transformations. The underlying theme of the show is identifying diet and healthy lifestyle myths, breaking them apart and replacing them with up to date science. If you want to understand why the world of nutrition science is filled with contradictions and controversy, you’ve come to the right place. One week you might hear about a doctor’s experience treating diabetics and the next week, what the chairman of NASA’s Advisory Council has to say about the latest scientific studies on ketogenic diets for athletic performance! Raphael’s passion for science communication and good fortune to have smart people speak with him publicly largely stems from him being a long-time podcast aficionado. The health and science podcast he recommends are Robb Wolf’s The Paleo Solution, Richard Morris and Carl Franklin’s 2 Keto Dudes, Rhonda Patrick’s Found My Fitness, Shawn Baker and Zach Bitter’s Human Performance Outliers, Christopher Kelly and Dr.Tommy Wood’s Nourish Balance Thrive, Chris Kresser’s Revolution Health Radio, Dawn Kernagis and Dr.Ford’s STEM-Talk, Jessie Lawler’s Smart Drug Smarts, Joe Rogan’s The Joe Rogan Experience, Dr.Attia’s The Drive, Dan Pardi’s HumanOS Radio and lastly Dr.Limanksy and Jimmy Moore’s The KetoHacking MD.
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Podcasts:
In episode 15 Gabor and I review two studies looking at liver health by linking the process of de novo lipogenesis, with the activity of mTORC2, ChREBP-β and SREBP1c.
In episode 14 Gabor and I review a study from 2015 paper looking at the knock-on effects of adapting to cold temperatures in terms of insulin sensitivity and the behavior of fat tissue.
Short summary: In episode 13 Gabor and I review a 2011 study looking at the metabolic consequences of rhesus monkeys being fed a grain-based diet supplemented with 500mL of fructose loaded Kool-Aid a day over a year.
Short summary: I talk to engineer Dave Feldman about what his dietary self-experiments taught him cholesterol in human physiology. His “N = 1” experimentation is not only very interesting and rigorous but most importantly, it cannot be explained by current mainstream notions in lipidology. We also discuss the implications that this may have for cardiovascular disease.
Short summary: In episode 11 Gabor selects 2 papers on the physiology of migrating birds that fatten up for their voyage and we discuss what this can tell us about human obesity. The first paper is from 2002 by Bairlein and is called “How to get fat: nutritional mechanisms of seasonal fat accumulation in migratory songbirds” http://www.ncbi.nlm.nih.gov/pubmed/12008967. The second is called “Adipose energy stores, physical work, and the metabolic syndrome: lessons from hummingbirds” http://www.ncbi.nlm.nih.gov/pubmed/16351726 and is by Hargrove et al. from 2005.
Short summary: With guest Ellen Davis we discuss the many medical applications of ketogenic and low carb diets, all of which is explored in depth in her 3 books “Fighting Cancer with a Ketogenic Diet”, “The Ketogenic Diet for Type 1 Diabetes” and “Conquering Type 2 Diabetes with a Ketogenic Diet”.
In her new book “The Alzheimer’s Antidote”, Amy Berger explains how improving one’s metabolism through a well-formulated low-carb high-fat diet is a worthwhile strategy to manage the disease. We then discuss how ‘excess protein’ is an overblown concern when it comes keeping adequately low blood sugar by not excessively stimulating gluconeogenesis. Lastly, we discuss the right and wrong reasons to sell and use exogenous ketones.
In episode 8 of the Break Nutrition show we discuss 2 papers which explore the glycemic, insulin and incretin responses and how the digestibility of starch as well as the apportioning of endogenous vs exogenous glucose comes into play. The paper from 2012 is “Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men” http://www.ncbi.nlm.nih.gov/pubmed/22990033. The paper from 2015 is “Plasma glucose kinetics and response of insulin and GIP following a cereal breakfast in female subjects: effect of starch digestibility” http://www.ncbi.nlm.nih.gov/pubmed/25852025.
In Episode 7 of the Break Nutrition show we discuss how changes in the cellular structure of starchy tubers and grains arising from certain types of food processing can disrupt our glycemic and insulin responses.
In Episode 6 of the Break Nutrition Show we discuss why bariatric surgery improves metabolic parameters quickly
The Break Nutrition Show provides a unique format to explore diet and health topics by alternating between in-depth technical discussions of specific research papers and shorter lay-friendly episodes on general health and nutrition questions
In Episode 4 of the Break Nutrition Show we discuss why the rate at which you absorb sugar may affect obesity, diabetes and general metabolic health
In Episode 3 of the Break Nutrition show we discussed rodent studies showing an insulin gene dosage-dependent effect on adiposity, the interplay between caloric restriction & circulating insulin, as well as how incretin hormones affect fat loss dynamics"
In Episode 2 of the BreakNutrition Show we talked about how dysregulated cycling of fat between fat cells, the liver and the fat we eat can lead to obesity
In Episode 1 of the BreakNutrition Show we talked about how how dysregulated fat flow from fat cells can drive the creation of new glucose in the liver and lead to diabetes
