Salicylate Overdose
Summary: <br> Salicylate toxicity is the great toxicologic mimicker!!! <br> <br> <br> <br> Step 1: When to Suspect Salicylate Overdose<br> <br> <br> <br> * Signs of CNS stimulation* Tachypnea* Hyperthermia* Altered mental status* Signs of GI irritation* Nausea/Vomiting* Abdominal pain* Common “mimicker”* Sepsis* Acute abdomen<br> <br> <br> <br> Step 2: Testing Plan<br> <br> <br> <br> * Electrolyte panel* Anion gap metabolic acidosis* Sodium – Chloride – Bicarb* Normal anion gap (AG) is <10* Caused by salicylic acid and lactic acid* Blood gas* Mixed respiratory ALKALOSIS and metabolic ACIDOSIS<br> <br> <br> <br> Step 3: Obtain Serum Salicylate Level<br> <br> <br> <br> Step 4: Treatment Plan<br> <br> <br> <br> * Mild salicylate toxicity* Alkalinize urine with sodium bicarbonate (NaHCO3) drip* Severe salicylate toxicity* Dialysis<br> <br> <br> <br> Additional Reading<br> <br> <br> <br> * Salicylate Poisoning <a href="https://litfl.com/salicylate-poisoning/#:~:text=%20Salicylate%20Poisoning%20%201%20nausea%2C%20vomiting%2C%20abdominal,oedema%20and%20ARDS%204%20cardiovascular%20instability%20More%20">(LITFL)</a><br>
