![VPR News show](https://d3dthqtvwic6y7.cloudfront.net/podcast-covers/000/045/750/small/vpr-news-from-vermont-public-radio.jpg)
Summary: Major depression can have devastating effects on a sufferer's life – and can be deadly. There are many treatments – different kinds of drugs, therapies, and other interventions – but what happens when someone can't find one that works? We're talking about treatment-resistant depression and how it's dealt with by patients and care providers.