![GuidePost, A Podcast Series from The CRISPR Journal show](https://d3dthqtvwic6y7.cloudfront.net/podcast-covers/000/093/662/small/guidepost-a-podcast-series-from-the-crispr-journal.jpg)
Summary: While postdocs in David Liu’s lab at Harvard University, Alexis Komor (UCSD) and Nicole Gaudelli (Beam Therapeutics) developed a pair of CRISPR-based molecular machines known as base editors, capable of engineering precise single-base substitutions with enormous basic research and therapeutic implications.