GI Pearls Podcast

Episode 62 Show Notes July 2023 * Comparison of endoscopic sleeve gastroplasty versus surgical sleeve gastrectomy: a database analysis. – GIE * Incidence and natural history of gastric high grade dysplasia in patients with FAP. – GIE * Association of Life Expectancy with surveillance colonoscopy findings and follow up recommendations in Older adults – Jama IM * Physician decision-making about surveillance in older adults with prior adenomas: results from a national study. – Am J Gastro * Hpylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT) – RCT – Lancet 2022 * Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridiodes difficile Infection – CGH Tweet

Episode 61 Show Notes June 2023 * Efficacy of a Second PPI Course After Steroid-induced remission in EOE refractory to initial PPI therapy. – ACG * AGA Clinical Practice Update on Management of Subepithelial Lesions encountered during routine Endoscopy: Expert Review – CGH * Prune juice Containing Sorbitol, Pectin and Polyphenol Ameliorates subjective complaints and Hard Feces while Normalizing Stool in Chronic constipation: A randomized placebo-controlleD Trial. – Am J Gastro * Adenoma Detection Rate and Risk for Interval Post colonoscopy Colorectal Cancer in Fecal Immunochemical Test–Based Screening – Annals of IM * Latiglutenase Protects the mucosa and attenuates symptom severity in patients with celiac disease exposed to a gluten challenge – Gastro * Evaluation of real-time computer-aided polyp detection system during screening colonoscopy: AI-DETECT study – Endoscopy Tweet

Show Notes for GI Pearls Episode 60 * What is the Prevalence of Clinically Significant Endoscopic Findings in Subjects With Dyspepsia? Updated Systematic Review and Meta-analysis – CGH* Quality of upper GI endoscopy: a prospective cohort study on impact of endoscopist education – GIE* Association between endoscopist specialty and colonoscopy quality: a systematic Review and meta-analysis. – CGH* Net Remission Rates with Biologic Treatment in Crohn’s  Disease: A Reappraisal of the Clinical Trial Data  – CGH Tweet

Show notes for Episode 59 GI Pearls Podcast * Cannabidiol for Functional Dyspepsia With Normal Gastric Emptying: a RCT. – Am J Gastro* Randomized Controlled Trial Investigating Cold Snare and Forceps Polypectomy among small POLYPs in Rates of Complete Resection: The TINYPOLYP Trial – Am J Gastro* Vonoprazan triple and dual therapy for Hpylori infection in the United States and Europe: RCT – Gastro* Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – NEJM Tweet

Episode 58 Show notes * Cold versus hot snare resection with or without submucosal injection of 6-15mm colorectal polyps: RCT. – GIE* Prospective cohort study to investigate the safety of preoperative tumor necrosis factor inhibitor exposure in patients with inflammatory bowel disease undergoing intra-abdominal surgery.  – Gastroenterology* Clip Closure does not reduce risk of bleeding after resection of large serrated polyps: Results from a randomized trial. – CGH Tweet

Articles discussed * Clinically significant serrated polyp detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry – GIE* Polyps seen but not removed during index colonoscopy: an underestimated inefficiency in endoscopy practice. – GIE* Fecal Microbiota transplant is a good treatment for recurrent C.difficile and there were several randomized clinical trials showing it’s efficacy, mostly small, but with really good results. Please send me comments, suggestions to info@gipearls dot com. If you could also leave a good review on iTunes or your podcatcher of choice – this would go a long way. Tweet

Episode 56 – New Short Format Articles discussed: * Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening: preliminary report of a randomised controlled trial – Lancet Gastro Hep* Vedolizumab is associated with a lower risk of Serious Infectious than Anti-Tumor Factors Agents in Older Adults – CGH please feel free to add your comments on https://gipearls.com/category/podcast/ – just select the episode and leave comments on the bottom of the page. Otherwise see you on twitter @GI_Pearls Tweet

Show notes for Episode 55 – June 2022 * Pooled Rates of Adenoma Detection by Colonoscopy in Asymptomatic Average Risk Individuals with Positive Fecal Immunochemical Test: A Systematic Review and Meta-Analysis – GIE* Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial – Annals of IM* Recurrence of Colorectal neoplastic polyps after incomplete resection  – annals of internal Medicine* A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being – Scientific Reports* Associations between autoimmune conditions and gastric cancer risk among elderly adults in the united states – Am J Gastro* Patient satisfaction of Propofol versus Midazolam and Fentanyl Sedation during colonoscopy in IBD – CGH* Comorbidities Drive the Majority of Overall Mortality in Low-risk Mucinous Pancreatic Cysts Under Surveillance – CGH* Implications of stable or increasing adenoma detection rate on the need for continuous measurement. – GIE* Margin marking before colorectal endoscopic mucosal resection and its impact on neoplasia recurrence. – GIE* Percutaneous Tibial nerve Stimulation vs Sham Stimulation For Fecal incontinence in Women: Neuromodulation for accidental bowel leakage Randomized Clinical Trial – ACG* ACG-CAG Clinical Practice Guideline :Management of Anticoagulants and Antiplatelets during acute GI bleed – ACG Guidelines Tweet

Show notes Episode 54 – May 2022 * A Randomized Controlled Trial of Cold Snare Polypectomy Technique: Technique Matters More Than Snare Wire Diameter – Am J Gastro* Outcomes for upper gastrointestinal bleeding during the first wave of the COVID-19 pandemic in the Toronto area – J Gastro and Hep * Endoscopic Surveillance of Barrett’s Esophagus – using old principles and new technology to improve Care. – Am J Gastro* Three signs of pneumoperitoneum on a Supine Radio-graph – CGH* Comparison of a Hemostatic Powder and Standard Treatment in the Control of Active Bleeding From Upper Nonvariceal Lesions – Annals of Int Medicine* Associations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance – ACG* Artificial intelligence for the assessment of bowel preparation – GIE* Diagnostic Yeild of colonoscopy in Patients with Symptoms Compatible with Rome IV Functional Bowel Disorders . – CGH Tweet

Show Notes for Episode 53 * Lyophilised oral fecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial. – Lancet Gastro* Effect of prophylactic endoscopic clip placement on clinically significant post-endoscopic mucosal resection bleeding in the right colon: a single centre, randomized controlled trial – Lancet Gastro* Feasibility and diagnostic yield of small-bowel capsule endoscopy in patients with surgically altered gastric anatomy: the SAGA study – GIE* Utility of Serum Biomarker Indices for staging of Hepatic Fibrosis before and after venesection in patients with Hemochromatosis caused by Variants in HFE – CGH* Barrett’s esophagus with low-grade dysplasia: high rate of upstaging at Barrett’s esophagus referral units suggests progression rates may be overestimated.  – GIE* ACG Clinical Guideline for the diagnosis and management of GERD – Am J Gastro* Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – ACP – Annals of IM Tweet

Episode 52 Show notes * Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis – NEJM* Benchmarking Adenoma Detection Rates for Colonoscopy: Results From a US-Based Registry – Am J Gastro* Colonoscopy-related Mortality in a Fecal-Immunochemical Test-based Colorectal Cancer Screening Program – CGH* AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in IBD – expert review – Gastro* Should Treatment Indications for Chronic Hepatitis B be  Expanded? – CGH* Urinary Cannabis Metabolite Concentrations in Cannabis Hyperemesis Syndrome  – JPGN* A randomized, Controled Trial of the Pan-PPAR Agonist Nanifibranor in NASH – NEJM* Prospective study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease – NEJM* Recommendation Reversals in Gastroenterology Clinical Practice Guidelines – J of Canadian A of Gastro Tweet

Show notes for Episode 51 * Role of routine second-look endoscopy in patients with acute peptic ulcer bleeding: meta-analysis of randomized controlled trials-  GIE* A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn’s Disease – Gastroenterology* Comparative effectiveness and harms of antibiotics for outpatient diverticulitis. – Annals of IM* Colonoscopy Versus Fecal Immunochemical Test for Reducing Colorectal Cancer Risk: A Population-Based Case–Control Study   – CTG* Combination therapy does not improve rate of clinical or endoscpic remission in patients with IBD treated with vedolizumab or ustekinumab. – CGH* World Gastroenterology Organisation Global Guidelines –  Helicobacter Pylori May 2021* Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome* Association between time to colonoscopy after positive fecal testing and colorectal cancer outcomes: Review – CGH* Intestinal Failure: What all gastroenterolgists should know-  CGH* ACG Clinical Guidelines: Prevention, Diagnosis and TReatment of Clostridioides difficile Infections – Am J Gastro Tweet

* Histologic Changes caused by Injection of a novel submucosal lifting agent for endoscopic resection in GI lesions. – GIE* Prevalence of Barrett’s Esophagus and performance of societal screening guidelines in an unreferred Primary care Population of US veterans.  – GIE* The usefulness of olive oil enema in children with severe chronic constipation – J Ped Surg* Rates of Postoperative Recurrence of Crohn’s Disease and Effects of Immunosuppresive and Biologic Therapies – CGH* Histopathologic features and fragmentation of polyps with cold snare defect protrusions. – GIE* AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis – Gastro* Management and outcomes of bleeding within 30 days of colonic polypectomy in a Large, Real-Life, Multicenter Cohort study. – CGH* Hypothermic Machine Perfusion in Liver Transplantation – NEJM* EUS-guided gallbladder drainage vs laparoscopic cholecystectomy for acute cholecystitis: a propensity score analysis with 1-year follow up data.  – GIE* The prevalence of small-bowel polyps on video capsule endoscopy in patients with sporadic duodenal or ampullary adenomas. – GIE* Adverse events and residual lesions rate after cold endoscopic mucosal resection of serrated lesions >10mm.* Colorectal EMR outcomes in octogenarians versus younger patients referred for removal of large (>20mm) non-pedunculated polyps. – GIE Tweet

Show notes for Episode 49 for April 2021 * Effectiveness of Oral Vancomycin for Prevention of Healtchare Facility-onset C.diff infection in Targeted Patients during Systemic antibiotic Exposure – Clinical ID* The Detrimental Effects of oral Vancomycin – Letter to Editor – Clinical ID* Linked color imaging focused on Neoplasm detection in the Upper GI tract – randomised trial  – Annals of Internal Medicine* AGA clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review* Comparative effectiveness and harms of antibiotics for outpatient diverticulitis: Two nationwide cohort studies. Ann Intern Med* Effects of Tenofovir vs Entecavir on Risk of HCC in patients with chronic HBV infection: A SRMA – CGH* Factors that affect adequacy of Colon cleansing for colonoscopy in Hospitalized Patients – CGH* https://app.calculoid.com/#/calculator/69490* ACG Clinical Guidelines: Colorectal Cancer Screening 2021 Tweet

Show notes for Episode  48 March 2021 * Younger physicians and longer withdwaral times are associated with detection of advanced neoplasia in a large community practice. – CGH* It’s All The RAVE: Time to Give up on “Chronic Radiation Proctitis” Misnomer – Gastroenterology* Local immune response to food antigens drives meal-induced abdominal pain – Nature* Prevalence of  a First-Degree Relative with Colorectal Cancer and Uptake of screening among persons 40-54 years old. – CGH* Prevalence of IBS-type symptoms in patients with IBD in remission: SRMA – Lancet:Gastro and Hep* Impact of 9-Minute Withdrawal Time on the Adenoma  Detection Rate: A Multicenter Randomized Controlled Trial –  CGH* Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial – BMJ* Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal gene Expression in Patients with Bile Acid Diarrhea in a Randomized Trial. – CGH* Possible tumour cell reimplantation during curative endoscopic therapy of superficial Barrett’s carcinoma – GUT* Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomized sham-controlled clinical trial. – GUT * Efficacy of Therapy for EOE in Real-World Practice – CGH* ACG Clinical Guideline: Management of Irritable Bowel Syndrome – ACG FYI – if you need me to send you the article, please e-mail me, and I will. Tweet